A pioneer in reproducible proteomic tools
These products include protein binding reagents, such as antibodies and immunoassays, and related reagents. Our RUO products are used to detect, quantify, visualize and modify proteins in scientific research experiments, serving as vital tools to enable our customers to develop insights about targets and biological pathways of interest.
Antibodies are a core component of many in vitro diagnostic assays and can also be used as therapeutic agents to treat many diseases, including cancer. Through custom development of new antibodies and out-licensing of our existing antibodies to biopharmaceutical and diagnostic companies, we are extending the commercial potential of our products into clinical applications
Scientists require high quality tools and reagents, which deliver consistent, reproducible results, save time, uncover deeper biological insights and advance their research.
Customers place their trust in Abcam because of our reputation for providing validated, reproducible products with market leading specificity and sensitivity, comprehensive and transparent product data, fast delivery and exceptional customer support.
According to CiteAb, our products were cited in approximately half of all life science publications in 2019, and we were the most cited company in approximately 40% of the top 2,000 most studied protein targets as of June 30, 2020.
We offer customers the latest research tools available globally through our online product catalogue as well as providing the option to create specific custom reagents for individual needs. We innovate and manufacture our own products in our specialist facilities worldwide, extending our offering through products supplied by our trusted partners.
Research use only antibodies
Antibodies are amongst the most commonly used tools in life science and clinical research for the study of proteins and their functions within various biological pathways and diseases.
We are a leading provider of antibodies as research reagents worldwide.
High-quality research antibodies are critical to scientists’ research and their ability to reproduce experiments, as unreliable research reagents lead to wasted time and money. We strive to offer high-quality antibodies that provide specificity, sensitivity and consistency, which helps to increase confidence in research outcomes and reduce waste across the industry.
In vitro diagnostic (IVD) antibodies
IVD-grade antibodies are typically employed in assays used in the clinical setting, such as a hospital, CLIA-accredited laboratory, or medical institute laboratory. These tools are used in immunoassays that assess patient samples, such as blood, urine or tissue, and help clinicians to diagnose or assess the progression of a disease. As a companion diagnostic, IVD assays can also provide information on the type of treatment to use and assist with disease prognosis.
In addition to our range of IVD-grade rabbit recombinant monoclonal antibodies we offer custom development, manufacture and commercial licensing of recombinant antibodies and immunoassays.
Conjugated antibodies and conjugation kits
More than 80% of antibody customers use conjugated antibodies for their research. Conjugation is the process of attaching a label to an antibody to enable visualization and measurement. Labels come in many forms, such as enzymes, fluorescent molecules and metals.
We offer a wide range of directly conjugated antibodies as well as offer antibody and protein conjugation labelling kits to enable customers to label their antibodies in their own laboratory.
Immunoassays – Singleplex and Multiplex
Immunoassays are tests that use one or more antibodies to detect and quantify a protein or specific molecule of interest known as an analyte, within a sample. They are important tools frequently used in biological research and in vitro diagnostics to accurately quantify levels of a particular analyte or to test for the presence of protein disease markers (biomarkers).
Depending on the application, immunoassays can be singleplex allowing the detection of a single analyte in a sample, or multiplex enabling multiple analytes to be simultaneously quantified with a single test.
Abcam has an extensive range of singleplex and multiplex immunoassays.
Proteins and peptides
Proteins are the molecules that carry out almost all of the actions and functions within and between cells. Major types of proteins include cytokines, which can initiate an immune response, growth factors, which help scientists culture cells in a laboratory, or enzymes, which catalyze reactions. Scientists use these proteins and peptides as part of more complex experiments to test how cells and organisms’ function.
We offer a comprehensive range of proteins and peptides, that includes in-house manufactured recombinant bioactive proteins that can be used from early stage research through development and into manufacturing.
Our newest range of premium grade bioactive proteins has been designed specifically for use in cell- and gene- therapy research and clinical manufacturing.
CRISPR gene-edited cell lines and lysates
Knockout (KO) cell lines play a significant role in the study and understanding of biological pathways and disease models. In addition, they are critical to the effective validation of key reagents such as antibodies, providing true negative controls for assessing an antibody’s specificity.
Ready-made KO cell lines, and the lysates derived from them, are an important emerging tool for helping to ensure reproducible science by helping remove the uncertainty in experimental data.
We have an award-winning program of reagent validation for our in-house recombinant monoclonal antibodies that is underpinned by an extensive portfolio of KO cell lines. These gold standard reagents are available to enable antibody validation for use across the life science community.
Agonists, antagonists, activators and inhibitors
Most of the work carried out in a cell is done by proteins: they form pumps to move chemicals in and out of the cell; act as chaperones to escort other molecules around the cell; and serve as intermediates that transmit signals between or within cells. Understanding how proteins function in their normal environment is vital.
It is also important to understand the impact of the presence of other proteins, potential therapeutics, and/or infectious disease agents like viruses, on their function. By regulating a protein’s activity, scientists can begin to understand its function.
We offer a wide variety of biochemicals – agonists, antagonists, activators, and inhibitors (AAAI) and supplementary products that are able to measure or change how a protein normally functions and help provide a more detailed understanding of the role and behaviour of proteins.
Our online portfolio offers approximately 100,000 products for order. These off-the-shelf products are available for research use only, supporting the understanding of the role of proteins in biological pathways.
Ultimately, findings from this work translates into tools to diagnose disease state, development of potential therapeutic treatments, advances in agriculture and environmental development, that all enhance health and wellbeing and positively impact society.
Watch our interview with Dr Bernd Gerhartz, VP of Technology Development